Can Monoclonal Antibodies promise coronavirus treatment? All you need to know
New Delhi | Jagran Trending Desk: For months, the world has been waiting for the COVID-19 vaccine with bated breath even as multiple medical-science groups are relentlessly working to identify a remedy that will end this pandemic. However, experts believe that the next big development could come from monoclonal antibodies that could act as a “bridge” drug that carries us safely forward until that time when a vaccine is available for wide dissemination.
Many researchers including US top infectious disease expert Dr Anthony Fauci have endorsed the development of monoclonal antibodies to target the virus. Mrs Fauci has called these manufactured to be a 'sure bet' against this SARS COV-2 virus. Monoclonal antibodies - grown in bioreactor vats - are copies of these naturally-occurring proteins.
Scientists are still working out the exact role of neutralizing antibodies in recovery from Covid-19, but drugmakers are confident that the right antibodies or a combination can alter the course of the disease that has claimed more than 675,000 lives globally.
"Antibodies can block infectivity. That is a fact," Regeneron Pharmaceuticals executive Christos Kyratsous told Reuters.
Regeneron is testing a two-antibody cocktail, which it believes limits the ability of the virus' to escape better than one, with data on its efficacy expected by late summer or early fall. "Protection will wane over time. Dosing is something we don't know yet," said Kyratsous.
The US government in June awarded Regeneron a $450 million supply contract. The company said it can immediately begin production at its U.S. plant if regulators approve the treatment.
Eli Lilly and Co
Even with that unusual cooperation among rivals, manufacturing these medicines is complex and capacity is limited. There is also a debate over whether a single antibody will be powerful enough to stop Covid-19.
AstraZeneca said it plans to start human trials of its dual-antibody combination within weeks.
Lilly, which began human testing in June of two antibody candidates in separate trials, is focusing on a one-drug approach.
"If you need a higher dosage or more antibodies, fewer people can be treated," Lilly Chief Scientific Officer Dan Skovronsky said.
Unlike vaccines, which activate the body's own immune system, the impact of infused antibodies eventually dissipates.
Still, drugmakers say monoclonal antibodies could temporarily prevent infection in at-risk people such as medical workers and the elderly. They could also be used as a therapeutic bridge until vaccines become widely available.
"In a prophylactic setting we think we may achieve coverage for up to six months," said Phil Pang, chief medical officer of Vir Biotechnology, which aims to start testing an antibody in non-hospitalized patients next month with partner GSK.
"The advantage of an antibody is that it is basically instant immunity," said Mark Brunswick, senior vice president at Sorrento Therapeutics, which aims to begin human trials next month of a single antibody candidate.
Safety risks for monoclonal antibodies are considered low, but their cost can be quite high. These type of drugs for cancer can cost over $100,000 a year.
There is also concern that the coronavirus could become resistant to specific antibodies. Researchers are already at work on second-generation compounds with targets other than the crown-like spikes the virus uses to invade cells.
"We are trying to develop something that is complementary," Amgen research chief David Reese said. Amgen is working with Adaptive Biotechnologies Corp.
Researchers in a recent paper published in the journal Nature said they had discovered several new, very potent, antibodies directed to an area where the virus attaches to human cells and to a region of the spike that has not attracted attention.
"To avoid development of resistance you want to target different sites," study author and Columbia University professor David Ho told Reuters.
There are also questions about when in the course of the illness it might be best to employ these new weapons. "Giving an antibody later on after infection might not be that helpful, said Florian Krammer, microbiology professor at New York's Icahn School of Medicine. "Given early, they probably work well."
(with inputs from Reuters)
Posted By: Rakesh Kumar Jha